MOTS-c Research Reference
A documentation-focused reference page for MOTS-c as a research compound. It describes the material, its research context, how purity and identity are verified, and how it is stored and handled in the lab. No effects are claimed. Supplied for research use only.
What it is
MOTS-c is a sixteen-residue mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome. Its reference sequence, MRWQEMGYIFYPRKLR, has been the form used across the published literature since the peptide was first described in 2015. As a research compound it is supplied as a lyophilized powder.
Research context
MOTS-c is characterized in laboratory research examining AMPK signaling, one-carbon metabolism, and mitochondrial-to-nuclear communication. This page notes the research areas in which the peptide is referenced; it makes no claim about any effect. A purity-verified reference preparation is useful in these contexts because it provides a defined, sequence-confirmed compound for study.
How purity is verified
The material is characterized per lot:
- HPLC for purity, read alongside the chromatogram; research-grade material is ≥99% by HPLC.
- Mass spectrometry for identity, matching the observed mass to the theoretical mass for the sixteen-residue sequence.
- LAL (Limulus Amebocyte Lysate) for bacterial endotoxin, commonly referenced to USP <85>.
All three results are documented on a lot-matched certificate tied to the lot number on the vial. Material is synthesized in the USA.
Storage and handling for lab use
General laboratory handling notes for lyophilized MOTS-c:
- Lyophilized powder. Store at -20°C. Keep the vial sealed and dry until ready to reconstitute.
- Reconstitution. Reconstitute with an appropriate solvent (bacteriostatic water is commonly referenced), adding slowly along the vial wall and swirling gently rather than shaking.
- Reconstituted solution. Commonly stored refrigerated at 2-8°C for optimal longevity. Avoid repeated freeze-thaw cycles.
Exact parameters depend on your protocol and the requirements of the work.
Documentation summary
MOTS-c reference material at Stacy & Chad is verified ≥99% by HPLC, confirmed by mass spectrometry, screened for endotoxin by LAL, synthesized in the USA, and shipped with a lot-matched certificate you can read before purchase. Supplied strictly for research use only.
Every lot ships with its own published COA.
Third-party HPLC purity, endotoxin screened, made in the USA — the certificate is on the product page before you buy. Buy 2, Get 1 Free + free shipping.
See the catalog →Frequently asked questions
What is MOTS-c?
MOTS-c is a sixteen-residue mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome, with the reference sequence MRWQEMGYIFYPRKLR. It is supplied as a lyophilized powder for research use.
What is the reference sequence for MOTS-c?
MRWQEMGYIFYPRKLR, the sixteen-residue form used across the published literature since the peptide was first described in 2015.
How is MOTS-c purity verified?
Per lot, using HPLC for purity (≥99% research-grade), mass spectrometry for identity against the sixteen-residue sequence, and the LAL assay for endotoxin, all documented on a lot-matched certificate of analysis.
How should MOTS-c be stored?
As a lyophilized powder at -20°C, kept sealed and dry until reconstitution. Reconstituted solution is commonly refrigerated at 2-8°C, with repeated freeze-thaw cycles avoided.
Is research MOTS-c for human use?
No. It is supplied for research use only, as a characterized laboratory reference compound, not for human, veterinary, or diagnostic use. ## Related pages - MOTS-c product page and lot COA - What third-party HPLC testing actually proves - Browse the research catalog